Let's consider the meaning of Mark 16:17-18 (KJV).
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Jesus, the apostles, and other disciples cast out demons (devils) often. And, the need to cast out demons is possibly or arguably greater today.
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Speaking with tongues, both in personal prayer life and for the purpose of giving interpretation before others are important gifts for operating in the power of the Holy Spirit.
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Taking up serpents has nothing to do with handling snakes. It's all about standing up to demonic strongholds, the head of which is that old serpent (the devil, or Satan).
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Protection against drinking any deadly thing applies to poisons in our environment, regardless of how they are placed there.
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Healing the sick - there is something about laying on of hands appropriately and in faith. We do this and see results. Amen
And these signs shall follow them that believe; In my name shall they
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cast out devils;
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they shall speak with new tongues;
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They shall take up serpents; and
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if they drink any deadly thing, it shall not hurt them;
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they shall lay hands on the sick, and they shall recover.